A new study from Curtin University in Western Australia has revealed that men carrying two copies of a common iron-related gene variant face more than double the risk of developing dementia. While having one copy of the H63D variant appears harmless, two copies significantly elevate risk in men—yet women seem largely unaffected. 🧠
The research analyzed data from over 19,000 participants in the ASPREE trial, a major international study on healthy aging. As co-author Prof. John Olynyk explained, "Having just one copy of this gene variant does not impact someone's health or increase their risk of dementia. However, having two copies more than doubled the risk in men." This finding highlights the potential for more personalized approaches in dementia prevention and treatment. 🔍
The study was a collaboration between Curtin University, Monash University, the University of Melbourne, and other major Australian institutions, underscoring the importance of understanding genetic influences on brain health. With over 400,000 Australians currently living with dementia, research like this is a crucial step toward innovative, targeted prevention strategies. 🚀
As scientists continue to explore the brain pathways affected by the H63D variant, there is hope that future treatments could reduce the damage leading to dementia. This breakthrough paves the way for a deeper understanding of how genetics can influence the risk of dementia, especially in men.
Reference(s):
Iron-related gene variant tied to higher dementia risk in men: study
cgtn.com
